Cisplatin efficacy

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August undefined, 2024

WebCisplatin is approved to be used alone or with other drugs to treat: Bladder cancer. It is used alone in patients with advanced cancer that cannot be treated with other therapies, … WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... 11 with an overall …

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WebClinical Comparative Investigation of Efficacy and Toxicity of Cisplatin plus Clinical comparative investigation of efficacy and toxicity of cisplatin plus gemcitabine or plus … WebOct 5, 2014 · Cisplatin is cleared by the kidney by both glomerular filtration and tubular secretion (Yao, Panichpisal et al., 2007; Ishida, Lee et al., 2002) Cisplatin … onpha innovation showcase

Cisplatin in cancer therapy: molecular mechanisms of action

WebDec 30, 2024 · Another large cohort study by Zhu et al [ 21] reported that weekly cisplatin was associated with ... WebFeb 16, 2024 · Warnings. Cisplatin can affect your nervous system, increase your risk of bleeding or infection, or harm your kidneys.. Call your doctor if you have a fever, mouth … WebThe efficacy of cisplatin must be improved for the treatment of UTUC because most patients with UTUC are older and may have renal insufficiency. The inadequate dose of cisplatin consequently leading to a poor outcome is a clinical challenge. onpha best deals

Cisplatin : an old drug with a newfound efficacy -- from

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WebThis enhanced drug efficacy could be attributable to Rev7’s ability to promote cisplatin resistance via the TLS DNA damage tolerance pathway and/or its regulation of DSB repair pathway choice. Indeed, Rev7 inactivation enhances cisplatin efficacy beyond that seen with disruption of other Pol ζ-components ( 5 ), suggesting that the effects of ... WebSep 15, 2024 · Cisplatin has activity against multiple tumor types and was approved for use by the United States in 1978. Current indications include testicular, ovarian and bladder cancer. It is also used in combination with other agents in … onpg molecular weightWebAn "accidental" discovery leads to cisplatin.Because platinum was thought to have no biological activity, Dr. Rosenberg and his colleagues put platinum electrodes into a solution containing the common laboratory bacteria E. … onpg what is it

"WebAug 8, 2024 · Background: Cisplatin is one of the frontline anticancer agents. However, development of cisplatin-resistance limits the therapeutic efficacy of cisplatin-based … " - Cisplatin efficacy

Cisplatin efficacy

WebDec 9, 2024 · But efficacy and toxicity of nedaplatin, lobaplatin and cisplatin haven’t been directly compared in concurrent chemo-radiotherapy in a study due to lack of head-to-head comparative trial. This retrospective study was done to compare short-term response rate, toxicity and long-term survival of cisplatin, nedaplatin and lobaplatin in concurrent ... WebNov 17, 2024 · Cisplatin has been widely used for a variety of cancer chemotherapies. In the guidelines for CINV, cisplatin is classified as a high-emetic-risk antineoplastic agent, and several agents – i.e. NK1 receptor antagonist (NK1RA), dexamethasone and 5-hydroxytryptamine-3 receptor antagonist (5-HT3RA) – are recommended for use with …

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WebApr 15, 2024 · A 64-year-old man exhibited lack of efficacy during treatment with pirarubicin, gemcitabine and cisplatin for metastatic, high-grade non-muscle invasive … WebNov 22, 2024 · 1:1 randomization between cisplatin alone, and cisplatin, sodium thiosulfate and mannitol. Masking: Single (Outcomes Assessor) Primary Purpose: Prevention: Official Title: A Multicenter Randomized Phase II Clinical Trial of the Efficacy of Sodium Thiosulfate and Mannitol in Reducing Ototoxicity in Adult Patients Receiving …

WebApr 11, 2024 · To evaluate if STAT3 KD can enhance the efficacy of cisplatin therapy for MB, we treated HD-shSTAT3 and ONS-shSTAT3 cells with an increasing concentration … WebCisplatin is a widely used cytotoxic agent approved in the treatment of bladder, ovarian, testicular, cervical, head and neck, and nonsmall cell lung cancer [ 1 – 3 ]. Cisplatin was first documented in 1847 by M. Peyrone, and it was approved by FDA for a variety of cancers in 1978.

WebApr 11, 2024 · Importantly, inhibition of STAT3 signaling significantly attenuated MB tumor growth in subcutaneous and intracranial orthotopic xenografts, increased the sensitivity of MB tumors to cisplatin, and improved the survival of … Webotoprotective effect, with maximum efficacy oc-curring when sodium thiosulfate is administered 4 to 8 hours after cisplatin,13-20 and that the ... be treated with cisplatin alone, they represent an

WebFeb 15, 2024 · Cisplatin plus anti-PD-1 antibody enhanced treatment efficacy in advanced esophageal squamous cell carcinoma Authors Wu Lin 1 2 , Jiong Qian 3 , Haohao Wang 1 , Ling Ren 2 , Yan Yang 1 , Chuanzhi Chen 1 , Xiangliu Chen 1 , Yingying Huang 1 , Jin Liu 1 , Nong Xu 3 , Lisong Teng 1 Affiliations

WebChemotherapeutics that damage DNA, such as cisplatin, have been the mainstay of cancer treatment for decades . However, all too often the efficacy of such DNA-damaging chemotherapy is severely limited by intrinsic and acquired drug resistance, as well as by the induction of secondary malignancies. inwove consultancyWebThe TPF triplet regimen (docetaxel, cisplatin, and 5‐FU) has a trend of further improving treatment efficacy compared with the traditional doublet regimen. 35 , 36 In a phase II … in worthingWebApr 5, 2024 · This is a single-arm, single-center, exploratory study, the purpose of this study is to evaluate the efficacy and safety of envafolimab combined with Chemoradiotherapy in participants with locally advanced cervical cancer. Condition or disease ... such as envafolimab and cisplatin; Subjects who have concomitant diseases that, in the ... onpg meaningWebSep 20, 2024 · Efficacy was evaluated in two multicenter open-label, randomized controlled trials in pediatric patients undergoing treatment with cisplatin-based chemotherapy for … onpg storageWebApr 14, 2024 · This overall positive outlook is marred by the development of resistance or reduced efficacy of the drug combinations, but the underlying mechanisms are somewhat unclear. It is interesting to note that cancer cells quickly adapt and evade most therapies by activating autophagy, a catabolic process designed to recycle damaged cellular … in wound healing zinc is needed forWebJul 8, 2024 · Multicenter, randomized, open-label, parallel group phase 2 study to assess the efficacy and tolerance of four combinations of CBP501, cisplatin, and nivolumab administered once every 21 days to patients with stage IV exocrine pancreatic cancer and WBC < 10,000/mm3 at screening. onpg extinction coefficientWebThe dose of cisplatin was reduced in 26 of 82 patients (31.7%) in the EP arm and in 25 of 82 patients (30.5%) in the IP arm. The mean (range) DI of cisplatin was 21.9 (14.3-26.8) mg/m 2 /wk in the EP arm and 13.6 (9.9 … onpg microbiology