WebTORC3 (transducer of regulated cAMP response element-binding protein 3), also known as CRTC3 (CREB-regulated transcription coactivator 3), is a 619 amino acid protein that localizes to both the cytoplasm and the nucleus and belongs to the TORC family. WebVectorBuilder Virus packaging for CRTC3-AS1 shRNA knockdown vectors (ie. lentivirus, AAV, adenovirus) Buy Clone products for research. Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling;

Transcriptional co-activator regulates melanocyte …

WebMay 18, 2024 · CRTC3 stimulates OCA2 expression by binding to CREB on a conserved enhancer, a regulatory site for pigmentation and melanoma risk. CRTC3 is uniquely activated by ERK1/2-mediated phosphorylation at Ser391 and by low levels of cAMP. Phosphorylation at Ser391 is constitutively elevated in human melanoma cells with … WebApr 15, 2024 · SIK2-shRNA demonstrated clear silencing efficacy . Both CSDS- and CUMS-exposed mice were intrahippocampally infused with SIK2-shRNA or control-shRNA, and behavioral tests were conducted 14 days after injection. Figure 5C ... It is interesting that hippocampal CRTC2 and CRTC3 levels were not affected by chronic stress, which … moby lonni

Research Paper CRTC3, a sensor and key regulator for …

WebJun 24, 2011 · SiO2 NPs-CRTC3-siRNA are effective to down-regulate RGS2 gene expression in HPAd without cytotoxic effects. The developed SiO2 NPs-CRTC3-siRNA … WebJul 27, 2016 · Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3. ... WebMay 2, 2011 · C57BL/6 mice (8–10 weeks) were injected with adenovirus expressing shRNA specific to mouse Crtc2, Crtc3, or lacZ (as a control) through the tail vein. Crtc2 or Crtc3 … mobyltics new cards