Hth-01-015
WebHTH-01-015 suppresses cell migration In NUAK1+/+ MEFs, and inhibit U2OS cell invasion. Moreover, HTH-01-015 inhibits cell proliferation in both cell lines. [1] HTH-01-015 … WebHTH-01-015 is a selective inhibitor of NUAK1 (IC 50 = 100 nM) and does not affect the activity of a panel of 139 other kinases, including additional AMPK family members. 1 At …
Hth-01-015
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http://www.woshika.com/k/MGIC-015.html WebTGF-β is a growth factor implicated in a plethora of processes and malignancies, which include cancer and fibrosis. Via binding to its receptor, TGF-β activates a complex intracellular signal transduction pathway, which is controlled by many forms of positive as well as negative feedback.
WebHTH-01-015 is a potent and selective NUAK1 inhibitor with IC50 of 100 nM, >100-fold selectivity over NUAK2. CAS No. 1613724-42-7 Selleck's HTH-01-015 has been cited by … Web1 jan. 2014 · WZ4003 and HTH-01-015 suppress NUAK1-mediated MYPT1 phosphorylation. To evaluate whether WZ4003 and HTH-01-015 could suppress NUAK activity in vivo, we …
Webhth-01-015是一种高特异性和高选择性的nuak1抑制剂，ic50值为100 nm[1]。 hth-01-015只抑制nuak激酶家族中的nuak1亚型，而对其它被测试的139个激酶没有显著的抑制活性 … WebThe results of the present study indicate that WZ4003 and HTH-01-015 will serve as useful chemical probes to delineate the biological roles of the NUAK kinases. Expand. 59. PDF. …
Web19 mrt. 2024 · In addition, we used a well-characterized NUAK1 inhibitor, HTH-01-015 (Banerjee et al., 2014a). Notably, potential off-target activities of BAY-880 greatly differed from those of HTH-01-015, arguing that joint targets of both inhibitors reflect on-target effects resulting from NUAK1 inhibition (Figure S4 B).
WebHTH-01-015 is a specific NUAK1 inhibitor. The related NUAK1 and NUAK2 are members of the AMPK (AMP-activated protein kinase) family of protein kinases that are activated by … halo top mint chipWebHTH-01-015 and WZ4003, Nuak1 and Nuak 1/2 inhibitors, respectively, have been shown to inhibit the phosphorylation of MYPT1 (myosin phosphate-targeting subunit 1), which is a … burlington county hazardous wasteWeb30 jul. 2024 · N-myristoyltransferase (NMT) inhibitors that were initially developed for treatment of parasitic protozoan infections, including sleeping sickness, malaria, and leismaniasis, have also shown great promise as treatment for oncological diseases. The successful transition of NMT inhibitors, which are currently at preclinical to early clinical … halo top mint chip ice creamWebName: HTH-01-015 CAS#: 1613724-42-7 Chemical Formula: C26H28N8O Exact Mass: 468.2386 Molecular Weight: 468.565 Elemental Analysis: C, 66.65; H, 6.02; N, 23.91; O, 3.41 Price and Availability Technical data Biological activity Solubility and formulation Protocols Calculators References burlington county health department opraWebSolubility. insoluble in H2O; ≥2.68 mg/mL in EtOH with gentle warming and ultrasonic; ≥7.85 mg/mL in DMSO with gentle warming. Chemical Name. N- [3- [5-chloro-2- [2-methoxy-4- … burlington county health and human servicesWebHTH-01-015 is a highly selective protein kinase inhibitor, which mainly affects ARK5 by inhibiting the phosphorylation of myosin phosphatase target subunit 1 (MYPT1), a substrate of ARK5 (125). halo top mint chip nutrition factsWebHTH-01-015 Solid 2887-5: 5 mg 2887-25: 25 mg See below SECTION 3: HAZARDS IDENTIFICATION Components CAS Number EC-No. Molecular Weight Chemical Formula HTH-01-015 1613724 -42 7 -- 468.55 C 26 H 28 N 8 O HTH-01-015: Emergency Overview: OSHA Hazards: No known OSHA hazards GHS Classification: Not a dangerous … burlington county hazardous waste facility