Splet30. okt. 2024 · CX-5461 is an Orally Active rRNA Synthesis Inhibitor. Above all, CX-5461 inhibits RNA Pol I-driven transcription of rRNA with IC 50 s of 142, 113, and 54 nM in HCT-116, A375, MIA PaCa-2 cells, respectively. Interestingly, CX-5461 shows little or no effect on Pol II (IC 50, ≥25 μM). Importantly, CX-5461 has modest inhibition on DNA ... Splet01. mar. 2008 · The proteins NCX1, NCX2, and NCX3 expressed on the plasma membrane of neurons play a crucial role in ionic regulation because they are the major bidirectional system promoting the efflux and influx of Na+ and Ca2+ ions. Here, we demonstrate that NCX1 and NCX3 proteins are novel additional targets for the survival action of the …
NCX1 and NCX3 as potential factors contributing to
Splet08. dec. 2024 · Results show that the Na (+)/Ca (2+) exchanger NCLX is enriched in mitochondria, where it is localized to the cristae. Thus, a dynamic relationship exists between calcium leak channels and calcium regulatory mechanisms in taste cells that functions to keep cytosolic calcium levels in the appropriate range for cell function. Protein samples were separated on 8 or 14% polyacrylamide gel and electrophoretically transferred onto nitrocellulose membranes. Filters were probed using the indicated primary antibodies: monoclonal anti-NCX1 (1 : 500; Swant, Bellinzona, Switzerland), polyclonal anti-NCX3 (1 : 4000; … Prikaži več Wild-type ncx3+/+ and knockout ncx3−/− mice22(provided by Dr. S Sokolow (UCLA School of Nursing, Los Angeles, CA, USA) and Dr. A Herchuelz … Prikaži več Total RNA was extracted from human MO3.13 cells using Trizol (Invitrogen, Milan, Italy). After DNase-I treatment (1 U/μl; Sigma-Aldrich) for 15 min at RT, the first-strand cDNA was synthesized using 5 μg of the total RNA … Prikaži več Confocal immunofluorescence procedures in cells or sections were performed as described previously.9, 36, 37 Mice were anesthetized intraperitoneally with chloral hydrate (300 mg/kg) … Prikaži več my junior is not adorable
Excitation-contraction coupling in heart cells. Roles of the sodium ...
SpletThe Na+/Ca2+exchanger (NCX) is a membrane antiporter that has been identified in the plasma membrane, the inner membrane of the nuclear envelope and in the membrane of … Splet01. feb. 2024 · The Na+/Ca2+exchanger (NCX) is a membrane antiporter that has been identified in the plasma membrane, the inner membrane of the nuclear envelope and in the membrane of the endoplasmic reticulum (ER). SpletThe Na(+)/Ca(2+) exchanger (NCX) is a membrane transporter that can switch Na(+) and Ca(2+) in either direction to maintain the homeostasis of intracellular Ca(2+). Three … old computer goodwill